We’re launching the third weekly compound prioritization sprint for the COVID Moonshot! This sprint focuses on our benzotriazole lead series. These compounds came about from a previous series of potent…
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Today, unsurprisingly, all our compute power is pointed squarely at COVID-19. But taking a step back, the broader impact of harnessing the compute power of hundreds of thousands of volunteers…
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Help us reach our weekend goal so the COVID Moonshot can make rapid progress toward a COVID-19 therapy! The First COVID Moonshot Weekly Sprint has just come to a close!…
Read moreMachine learning encompasses tools and algorithms that are now becoming popular in almost all scientific and technological fields. This is true for molecular dynamics as well, where machine learning offers promises of extracting valuable information from the enormous amounts of data generated by simulation of complex systems. We provide here a review of our curre…
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Join our weekly sprints to prioritize compounds to make and test!
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Maxwell I Zimmerman, Justin R Porter, Michael D Ward, Sukrit Singh, Neha Vithani, Artur Meller, Upasana L Mallimadugula, Catherine E Kuhn, Jonathan H Borowsky, Rafal P Wiewiora, Matthew F D Hurley, Aoife M Harbison, Carl A Fogarty, Joseph E Coffland, Elisa Fadda, Vincent A Voelz, John…
Read moreMyosin motor domains perform an extraordinary diversity of biological functions despite sharing a common mechanochemical cycle. Motors are adapted to their function, in part, by tuning the thermodynamics and kinetics of steps in this cycle. However, it remains unclear how sequence encodes these differences, since biochemically distinct motors often have nearly indistinguishable crystal structures. We hypothesized that sequences produce distinct biochemical phenotypes by modulating the r…
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Folding@home Consortium scientists have been working hard over the past three months to support experimental collaborators working to develop new therapies for COVID-19. One of these experimental collaborations is with the COVID Moonshot,…
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Ion channels act as doors for cells: they open and close to let in and out the particles that carry electrical charge, the ions. Ion channels are therefore at the…
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In response to popular demand, we have created an update to the Folding@home software that allows you to prioritize COVID-19 projects. We encourage you to upgrade as the new software…
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