Early during the COVID-19 pandemic, our simulations of the coronavirus spike protein led us to predict that it opens up far more widely than previously thought. This opening reveals ācrypticā…
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About 2,300,000 people are diagnosed with breast cancer every year. Of these, approximately 70,000 have mutations in the breast cancer gene 1 (BRCA1), which encodes the BRCA1 protein. BRCA1 plays…
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Please join us as we Stand Up for Science in cities across the US on Friday March 7. You can find more details on the main event in Washington DC…
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If you haven’t already, we invite you to check out the latest release of the Folding@home client (v8.4.9)! This version makes it much easier to create and join teams. You…
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Thanks to everyone who participated in Folding@home this past year, and happy new year to you and yours! With your help, we’ve made a lot of progress towards understanding biology…
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There has been growing interest in developing drugs that bind two or more proteins to āglueā them together. Tacrolimus (aka FK506) is a famous example. Ā Tacrolimus is an immune-suppressant that…
Read moreA central goal of Folding@home is to use distributed computing to solve problems that would otherwise be intractable. Ā Protein folding is a terrific problem to address with this approach:…
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Computational chemistry and machine learning continue to play an increasing role in drug discovery. One advance has been the increased accuracy with which we can predict the affinity of…
Read morePeptides are short proteins. For proteins, one typically envisions a long chain of amino acids that has folded up on itself to form a compact blob that is capable of…
Read moreOne of the Bowman labās major foci is on finding and targeting cryptic pockets. Cryptic pockets are absent in experimentally derived structures of what a protein typically looks like but…
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