Early during the COVID-19 pandemic, our simulations of the coronavirus spike protein led us to predict that it opens up far more widely than previously thought. This opening reveals ‘cryptic’…
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This past year, we have largely focused on following through on our commitment to take on SARS-CoV-2. Looking ahead, there’s more work to be done on the pandemic, and we…
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Rev up your GPUs and help us in the final stretch of nominating a patent-free oral antiviral for preclinical studies!
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Folding@home helps experimental collaborators understand mutations that drive increased fitness of SARS-CoV-2 mutants.
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We’re thrilled to report that the COVID Moonshot has been awarded a $10M grant from the Wellcome Trust on behalf of the World Health Organization (WHO) Access to COVID Tools…
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Sprint 10 aims to help optimize the P1 pocket substituent to work around metabolism issues with our current best lead compounds. We’ve been quiet lately, but that’s because we’ve been…
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TL;DR: During 2020, Folding@home was like the citizens’ fleet in the movie Star Wars: The Rise of Skywalker. Everyone came together to face a common foe, in this case the…
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As we all know, coronaviruses are a major threat to human health. In the past two decades these viruses have caused three epidemics: SARS in 2004, MERS in 2012, and…
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Sprint 5 to prioritize compounds for the open science patent-free COVID Moonshot drug discovery project has launched! Rev up your GPUs to help develop a new therapy.
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Several antibodies are now in clinical trials to both treat and provide protection against COVID-19. But one of these binds in a completely surprising way, and in a manner that may head off viral resistance. How does it work? We’re trying to find out!
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