Early during the COVID-19 pandemic, our simulations of the coronavirus spike protein led us to predict that it opens up far more widely than previously thought. This opening reveals ‘cryptic’…
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If you haven’t already, we invite you to check out the latest release of the Folding@home client (v8.4.9)! This version makes it much easier to create and join teams. You…
Read moreA central goal of Folding@home is to use distributed computing to solve problems that would otherwise be intractable. Â Protein folding is a terrific problem to address with this approach:…
Read morePeptides are short proteins. For proteins, one typically envisions a long chain of amino acids that has folded up on itself to form a compact blob that is capable of…
Read moreOne of the Bowman lab’s major foci is on finding and targeting cryptic pockets. Cryptic pockets are absent in experimentally derived structures of what a protein typically looks like but…
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When it comes to designing novel drugs, achieving specificity is a major challenge. An effective drug must bind tightly to its target protein while avoiding unwanted side effects that can…
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and Viktor Belay Section 1: How does the breakdown of a brain cell’s recycling plant lead to neurodegenerative disease? Cellular functions are dependent on the activity of a vast ensemble…
Read moreApologies to all for the unexpected downtime of the forum. An auto-update to the SSL certificate failed to go through and fixing it was delayed by the holidays. We hope…
Read moreHello Folders! We’ve been made aware of a potential issue for users who are using certain advanced manual configuration options for remote client management using fah-control. We actively recommend against…
Read moreIt’s always fun to watch the number of CPUs and GPUs running Folding@home! Earlier this year was particularly exciting as we saw explosive growth in Folding@home in response to our…
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