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Category: Folding@home Blog

Towards physics-based precision medicine

May 30, 2024 by Greg Bowman

The goal of precision medicine is to utilize our knowledge of the molecular causes of disease to better diagnose and treat patients. In the precision medicine framework, diseases are subdivided…

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How does ApoE cause Alzheimer’s disease?

May 16, 2024 by Greg Bowman

A number of active projects on Folding@home right now aim to understand how different forms of the protein apolipoprotein E (ApoE) determine one’s risk of developing Alzheimer’s disease. Alzheimer’s disease…

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AlphaFold opens new opportunities for Folding@home

May 2, 2024 by Greg Bowman

Folding@home has long sought to understand how proteins self-assemble, or fold, into their functional structures and what the functional implications of dynamics within the context of a folded protein are.…

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Unraveling the Mystery of Drug Specificity: The Case of Blebbistatin

November 30, 2023 by Greg Bowman

When it comes to designing novel drugs, achieving specificity is a major challenge. An effective drug must bind tightly to its target protein while avoiding unwanted side effects that can…

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Unraveling the Secrets of G Protein Activation: A Molecular Odyssey

November 6, 2023 by Greg Bowman

G proteins are essential molecular players in the intricate symphony of cellular signaling. From our vision to our sense of smell, neurotransmission to cell growth, G proteins are at the…

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Meet the classic paper: Sorin and Pande 2005

March 17, 2022 by Vincent Voelz
Figure 12 from the Sorin and Pande 2005 paper on helix-coil kinetics, showing complex kinetics between a surprising variety of non-helical states as well.

We revisit a classic paper from Folding@home’s early days in which the supposedly simple dynamics of a simple peptide turns out to be much more exciting than expected.

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Evaluating protein force fields

January 31, 2022 by Angela Bowman
Ribbon diagram of the Trp cage 20 amino acid miniprotein

New projects from the Voelz lab focus on assessing how well modern force fields can model proteins, the biological machines of the cell.

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2021 in review, and happy new year 2022

January 3, 2022 by Greg Bowman
World map showing global distribution of Folding@home users from Nature Chemistry 13:651–659, 2021 paper.

This past year, we have largely focused on following through on our commitment to take on SARS-CoV-2. Looking ahead, there’s more work to be done on the pandemic, and we…

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COVID MOONSHOT SPRINT 11: The home stretch

December 27, 2021 by John Chodera
Spirocyclic compound scaffold used as the basis for COVID Moonshot Sprint 11

Rev up your GPUs and help us in the final stretch of nominating a patent-free oral antiviral for preclinical studies!

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Classic paper: Improved coarse-graining of Markov state models via explicit consideration of statistical uncertainty

December 9, 2021 by Anton Thynell
Hierarchy of microstate clusters into macrostates achieved with Bayesian Agglomerative Clustering (BACE)

This classic paper from Folding@home Director Greg Bowman describes a Bayesian approach to clustering microstates into metastable states for building Markov state models, a foundational Folding@home technology.

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