COVID MOONSHOT SPRINT 11: The home stretch
Rev up your GPUs and help us in the final stretch of nominating a patent-free oral antiviral for preclinical studies!
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Classic paper: Improved coarse-graining of Markov state models via explicit consideration of statistical uncertainty
This classic paper from Folding@home Director Greg Bowman describes a Bayesian approach to clustering microstates into metastable states for building Markov state models, a foundational Folding@home technology.
Read moreCOVID Moonshot funded by COVID-19 Therapeutics Accelerator to rapidly develop a safe, globally accessible and affordable antiviral pill
We’re thrilled to report that the COVID Moonshot has been awarded a $10M grant from the Wellcome Trust on behalf of the World Health Organization (WHO) Access to COVID Tools…
Read moreSimulating apoE variants to understand their role in Alzheimer’s Disease
Contributed by Justin Miller, Bowman Lab Alzheimer’s disease (AD), a dementia characterized by loss of memory and cognitive abilities, afflicts over an estimated 44 million people worldwide. While recent clinical…
Read moreCOVID Moonshot Sprint 10
Sprint 10 aims to help optimize the P1 pocket substituent to work around metabolism issues with our current best lead compounds. We’ve been quiet lately, but that’s because we’ve been…
Read moreUnderstanding the impact of the lipid bilayer on ion channel function
Contributed by Sergio Perez Conesa All our thoughts, movements, and heartbeats are governed by electrical signals in our bodies. These electrical signals are nothing but charged particles, called ions, crossing…
Read moreMaximizing the impact of Folding@home by engaging industry collaborators
For over 20 years, Folding@home has relied almost exclusively on government agencies like the National Science Foundation (NSF) and National Institutes of Health (NIH) for financial support. We’ve also been…
Read more2020 in review, and happy new year 2021!
TL;DR: During 2020, Folding@home was like the citizens’ fleet in the movie Star Wars: The Rise of Skywalker. Everyone came together to face a common foe, in this case the…
Read moreSARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential
As we all know, coronaviruses are a major threat to human health. In the past two decades these viruses have caused three epidemics: SARS in 2004, MERS in 2012, and…
Read moreUpdate for Those Using Advanced Remote Client Management Configurations
Hello Folders! We’ve been made aware of a potential issue for users who are using certain advanced manual configuration options for remote client management using fah-control. We actively recommend against…
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