Towards physics-based precision medicine
The goal of precision medicine is to utilize our knowledge of the molecular causes of disease to better diagnose and treat patients. In the precision medicine framework, diseases are subdivided…
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How does ApoE cause Alzheimer’s disease?
A number of active projects on Folding@home right now aim to understand how different forms of the protein apolipoprotein E (ApoE) determine one’s risk of developing Alzheimer’s disease. Alzheimer’s disease…
Read moreAlphaFold opens new opportunities for Folding@home
Folding@home has long sought to understand how proteins self-assemble, or fold, into their functional structures and what the functional implications of dynamics within the context of a folded protein are.…
Read moreNew Folding@home software in beta
The beta release of our new client software is going well. Thanks to everyone who has tried it out and given us feedback! If you haven’t already, you can download…
Read moreUnraveling the Mystery of Drug Specificity: The Case of Blebbistatin
When it comes to designing novel drugs, achieving specificity is a major challenge. An effective drug must bind tightly to its target protein while avoiding unwanted side effects that can…
Read moreUnraveling the Secrets of G Protein Activation: A Molecular Odyssey
G proteins are essential molecular players in the intricate symphony of cellular signaling. From our vision to our sense of smell, neurotransmission to cell growth, G proteins are at the…
Read moreUnderstanding Druggable States in a Protein Implicated in Parkinson’s Disease
and Viktor Belay Section 1: How does the breakdown of a brain cell’s recycling plant lead to neurodegenerative disease? Cellular functions are dependent on the activity of a vast ensemble…
Read moreMeet the classic paper: Sorin and Pande 2005
We revisit a classic paper from Folding@home’s early days in which the supposedly simple dynamics of a simple peptide turns out to be much more exciting than expected.
Read moreEvaluating protein force fields
New projects from the Voelz lab focus on assessing how well modern force fields can model proteins, the biological machines of the cell.
Read moreUnprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction
Over 1.8 milliseconds of simulation time on Folding@home helps understand a new class of stapled peptide therapeutics that show enhanced inhibition of cancer cell growth.
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