Over half of all known cancers involve some mutation in p53, the so-called guardian of the cell. p53 is a tumor-suppressor which signals for cell death if DNA gets damaged.
Without p53, damaged DNA can lead to the unusual growths found in cancer tumors. When p53 breaks down and does not fold correctly, then DNA damage goes unchecked and mutations can proliferate. We have been studying specific domains of p53 in order to predict mutations relevant in cancer and to study known cancer-related mutants.
FAH researchers Dr. Diwakar Shukla and Dr. Morgan Lawrenz have been using Folding@home to understand the fundamental behavior of kinases, key molecular targets in cancer. A paper on these results…Read more
We are simulating many forms of Pin1 WW domain, a protein implicated in some cancers and Alzheimer’s disease. Understanding the role of mutations on misfolding can have important biomedical consequences.Read more
At FAHcon 2012, Dr. Xuhui Huang presented our recent results of the molecular mechanisms of gene transcription. Transcription is the first step in reading genomic DNA, and regulation of this…Read more
In collaboration with the Nanomedicine Center for Protein Folding, we have been using our methods to further push a chaperonin inhibitor. This next round will use new scoring functions from…Read more