Alzheimer’s Disease (AD) is caused by the aggregation of relatively small (42 amino acid) proteins, called Abeta peptides. These proteins form aggregates which even in small clumps appear to be toxic to neurons and cause neuronal cell death involved in Alzheimer’s Disease and the horrible neurodegenerative consequences. It’s a challenge to study these aggregates, even with simulations.
We have many calculations being performed on AD. Our primary goals are the prediction of AD aggregate structure for rational drug design approaches as well as further insight into how AD aggregates form kinetically (hopefully paving the way for a method to stop the AD aggregate formation). We have made great progress towards this end.
We presented our results regarding new possible drugs (small molecule leads) to fight Alzheimer’s Disease at a recent meeting at Stanford, supported by the NIH Roadmap Nanomedicine center and NIH…Read more
The first of the papers has come out (see paper #58 on our Results page: “Simulating oligomerization at experimental concentrations and long timescales: A Markov state model approach”). In many…Read more