Evaluating protein force fields
New projects from the Voelz lab focus on assessing how well modern force fields can model proteins, the biological machines of the cell.
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COVID MOONSHOT SPRINT 11: The home stretch
Rev up your GPUs and help us in the final stretch of nominating a patent-free oral antiviral for preclinical studies!
Read moreCirculating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
Folding@home helps experimental collaborators understand mutations that drive increased fitness of SARS-CoV-2 mutants.
Read moreCOVID Moonshot funded by COVID-19 Therapeutics Accelerator to rapidly develop a safe, globally accessible and affordable antiviral pill
We’re thrilled to report that the COVID Moonshot has been awarded a $10M grant from the Wellcome Trust on behalf of the World Health Organization (WHO) Access to COVID Tools…
Read moreSimulating apoE variants to understand their role in Alzheimer’s Disease
Contributed by Justin Miller, Bowman Lab Alzheimer’s disease (AD), a dementia characterized by loss of memory and cognitive abilities, afflicts over an estimated 44 million people worldwide. While recent clinical…
Read moreCOVID Moonshot Sprint 10
Sprint 10 aims to help optimize the P1 pocket substituent to work around metabolism issues with our current best lead compounds. We’ve been quiet lately, but that’s because we’ve been…
Read moreUnderstanding the impact of the lipid bilayer on ion channel function
Contributed by Sergio Perez Conesa All our thoughts, movements, and heartbeats are governed by electrical signals in our bodies. These electrical signals are nothing but charged particles, called ions, crossing…
Read more2020 in review, and happy new year 2021!
TL;DR: During 2020, Folding@home was like the citizens’ fleet in the movie Star Wars: The Rise of Skywalker. Everyone came together to face a common foe, in this case the…
Read moreProtein folding and related problems remain unsolved despite AlphaFold’s advance
TL;DR: DeepMind’s AlphaFold marks a tremendous advance in our ability to predict the dominant structure of a protein. How proteins get there, and many other problems related to protein folding,…
Read moreCOVID Moonshot Sprint 5
Sprint 5 to prioritize compounds for the open science patent-free COVID Moonshot drug discovery project has launched! Rev up your GPUs to help develop a new therapy.
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