Happy 2026! (belated)
Thanks to everyone who helped get a lot of great science done in 2025! We’re looking forward to a great 2026 with you! First, the good stuff! Folding@home is continuing…
Read moreCategory: Infectious diseases
Experimental confirmation of spike dynamics
Early during the COVID-19 pandemic, our simulations of the coronavirus spike protein led us to predict that it opens up far more widely than previously thought. This opening reveals ‘cryptic’…
Read more2021 in review, and happy new year 2022
This past year, we have largely focused on following through on our commitment to take on SARS-CoV-2. Looking ahead, there’s more work to be done on the pandemic, and we…
Read moreCOVID MOONSHOT SPRINT 11: The home stretch
Rev up your GPUs and help us in the final stretch of nominating a patent-free oral antiviral for preclinical studies!
Read moreCirculating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
Folding@home helps experimental collaborators understand mutations that drive increased fitness of SARS-CoV-2 mutants.
Read moreCOVID Moonshot funded by COVID-19 Therapeutics Accelerator to rapidly develop a safe, globally accessible and affordable antiviral pill
We’re thrilled to report that the COVID Moonshot has been awarded a $10M grant from the Wellcome Trust on behalf of the World Health Organization (WHO) Access to COVID Tools…
Read moreCOVID Moonshot Sprint 10
Sprint 10 aims to help optimize the P1 pocket substituent to work around metabolism issues with our current best lead compounds. We’ve been quiet lately, but that’s because we’ve been…
Read more2020 in review, and happy new year 2021!
TL;DR: During 2020, Folding@home was like the citizens’ fleet in the movie Star Wars: The Rise of Skywalker. Everyone came together to face a common foe, in this case the…
Read moreSARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential
As we all know, coronaviruses are a major threat to human health. In the past two decades these viruses have caused three epidemics: SARS in 2004, MERS in 2012, and…
Read moreCOVID Moonshot Sprint 5
Sprint 5 to prioritize compounds for the open science patent-free COVID Moonshot drug discovery project has launched! Rev up your GPUs to help develop a new therapy.
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