Folding@home has long sought to understand how proteins self-assemble, or fold, into their functional structures and what the functional implications of dynamics within the context of a folded protein are.…
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When it comes to designing novel drugs, achieving specificity is a major challenge. An effective drug must bind tightly to its target protein while avoiding unwanted side effects that can…
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G proteins are essential molecular players in the intricate symphony of cellular signaling. From our vision to our sense of smell, neurotransmission to cell growth, G proteins are at the…
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We revisit a classic paper from Folding@home’s early days in which the supposedly simple dynamics of a simple peptide turns out to be much more exciting than expected.
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New projects from the Voelz lab focus on assessing how well modern force fields can model proteins, the biological machines of the cell.
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This past year, we have largely focused on following through on our commitment to take on SARS-CoV-2. Looking ahead, there’s more work to be done on the pandemic, and we…
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Rev up your GPUs and help us in the final stretch of nominating a patent-free oral antiviral for preclinical studies!
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This classic paper from Folding@home Director Greg Bowman describes a Bayesian approach to clustering microstates into metastable states for building Markov state models, a foundational Folding@home technology.
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We’re thrilled to report that the COVID Moonshot has been awarded a $10M grant from the Wellcome Trust on behalf of the World Health Organization (WHO) Access to COVID Tools…
Read moreContributed by Justin Miller, Bowman Lab Alzheimer’s disease (AD), a dementia characterized by loss of memory and cognitive abilities, afflicts over an estimated 44 million people worldwide. While recent clinical…
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