Breast Cancer and Her2 Kinase: Projects 9104-9114
We are continuing to make a big push into studying cancer. Next up, is work relevant for breast cancer. Specifically, we have started to study the Her2 Kinase, a part…
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New projects to help design selective inhibitors of protein methyltransferases
The Chodera lab has teamed up with Luo lab at MSKCC to study another important class of cancer targets: protein methyltransferases. These are protein-modifying enzymes that catalyze the transfer of…
Read moreInvestigating conformations accessible by Abl kinase- drug target for chronic myelogenous leukemia
Guest post by Sonya Hanson, postdoc in the Chodera lab. (Project 10472) We’re working our way through the kinase family here at the Chodera lab. You may have seen Danny’s…
Read moreResults of a kinase study published
The paper on the results of a kinase study conducted by Dr. Diwakar Shukla and his fellow researchers has been published. This kinase under investigation is c-src, which has been…
Read moreFighting cancer on Folding@Home: EGFR
[Guest post by Daniel L. Parton of the Chodera Lab, Memorial Sloan-Kettering Cancer Center.] We’re about to roll out our first major F@h project on the new work server at…
Read moreUsing Folding@home to understand the fundamental behavior of kinases
FAH researchers Dr. Diwakar Shukla and Dr. Morgan Lawrenz have been using Folding@home to understand the fundamental behavior of kinases, key molecular targets in cancer. A paper on these results…
Read moreAssisting Chris Garcia’s lab with their work with Interleukin 2 (IL-2)
We assisted Chris Garcia’s lab with their work with Interleukin 2 (IL-2), a protein which assists the immune system in fighting pathogens and cancer tumors. While injecting a patient with…
Read moreSimulating forms of Pin1 WW domain
We are simulating many forms of Pin1 WW domain, a protein implicated in some cancers and Alzheimer’s disease. Understanding the role of mutations on misfolding can have important biomedical consequences.
Read moreStudying the folding of ubiquitin
We’re studying the folding of ubiquitin, a small regulatory protein found in almost all cells in human body. It is part of a large regulatory system that labels other unneeded…
Read moreRecent results presented at FAHcon 2012
At FAHcon 2012, Dr. Xuhui Huang presented our recent results of the molecular mechanisms of gene transcription. Transcription is the first step in reading genomic DNA, and regulation of this…
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