Lin YS, Pande VS. Biophysical Journal (Dec 2012) SUMMARY. This details some new results from Folding@home on Alzheimer’s Disease. ABSTRACT. Amyloid beta (Aβ) peptide plays an important role in Alzheimer’s…
Read moreRing AM, Lin JX, Feng D, Mitra S, Rickert M, Bowman GR, Pande VS, Li P, Moraga I, Spolski R, Ozkan E, Leonard WJ, Garcia KC. Natural Immunology (Dec 2012)…
Read moreWalker JR, Novick PA, Parsons WH, McGregor M, Zablocki J, Pande VS, Du Bois J. Proceedings of the National Academy of Sciences, USA (Dec 2012) SUMMARY. Here we use molecular…
Read moreBeauchamp KA, McGibbon R, Lin YS, Pande VS. Proceedings of the National Academy of Sciences, USA (Oct 2012) SUMMARY. Markov State Models (MSMs) have been very helpful in analyzing protein…
Read moreVoelz VA, Jäger M, Yao S, Chen Y, Zhu L, Waldauer SA, Bowman GR, Friedrichs M, Bakajin O, Lapidus LJ, Weiss S, Pande VS. Journal of the American Chemical Society…
Read moreA. M. Levin, D. L. Bates, A. M. Ring, J. T. Lin, L. Su, C. Krieg, G. R. Bowman, P. Novick, V. S. Pande, H. E. Kohrt, O. Boyman, C.…
Read moreY-S Lin, G. R. Bowman, K. Beauchamp, and V. S. Pande Biophysical Journal, volume 102, pages 315-324 (2012) ABSTRACT. The aggregation of amyloid beta (Aβ) peptides plays an important role…
Read moreT.J. Lane and V.S. Pande The Journal of Physical Chemistry B (2012) ABSTRACT. A simple model is presented that describes general features of protein folding, in good agreement with experimental…
Read morePaul A. Novick, Dahabada H. Lopes, Kim M. Branson, Alexandra Esteras-Chopo, Isabella A. Graef, Gal Bitan, and Vijay S. Pande Journal of Medicinal Chemistry (2012) SUMMARY. These results have been…
Read moreInterleukin 15 (IL-15) and IL-2 have distinct immunological functions even though both signal through the receptor subunit IL-2Rβ and the common γ-chain (γ(c)). Here we found that in the structure of the IL-15-IL-15Rα-IL-2Rβ-γ(c) quaternary complex, IL-15 binds to IL-2Rβ and γ(c) in a heterodimer nearly indistinguishable from that of the IL-2-IL-2Rα-IL-2Rβ-γ(c) complex, despite their different receptor-binding chemistries. IL-15Rα substantially increased the affinity of IL-15 for IL-2Rβ, a…
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