Acc Chem Res. 2015 Feb 17;48(2):414-22 Authors: Shukla D, Hernández CX, Weber JK, Pande VS. Protein function is inextricably linked to protein dynamics. As we move from a static structural…
Read moreLawrenz M1, Shukla D2, Pande VS. Sci Rep. 2015; 5: 7918. We describe an innovative protocol for ab initio prediction of ligand crystallographic binding poses and highly effective analysis of…
Read moreI’m happy to announce that October 1, 2015 is Folding@home’s 15th birthday.  It’s amazing for me to look back at all we’ve done together, all we’ve built, and all that’s…
Read moreIn collaboration with Sony, we brought Folding@home to Sony Mobile phones. During the months that followed the mobile application was made available with broader Android support.
Read morePeople around the world are continuing to help advance research by downloading and running Folding@home mobile. Here is an image of the global usage distribution of our Mobile Client created…
Read moreMutation to the tumor-suppressor protein p53 is a common feature in most cancers. MDM2–a protein whose job it is to downregulate p53 via their direct binding interaction–has therefore become a…
Read moreWe’re proud to announce the first full version of our Folding@Home client for Android Mobile phones.  This version is available to all Android Mobile phones with version 4.4 (Kitkat) and…
Read moreWe present an analysis of the most extensive explicit-solvent simulations of β-hairpins to date (9.4 ms in aggregate), with the aim of probing the effects of tryptophan mutations on folding. From molecular simulations of GB1 hairpin, trpzip4, trpzip5, and trpzip6 performed on Folding@home, Markov State Models (MSMs) were constructed using a unified set of metastable states, enabling objective comparison of folding mechanisms. MSM models display quantitative agreement with experimental structur…
Read moreWe see that there is an issue with our NaCl Client (at http://nacl.foldingathome.org), with donors seeing this error: Warning: Unexpected response to AS assignment request: error,DB ERROR: IO error: log.leveldb/016519.ldb:…
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