Better folding through biased simulations
A central goal of Folding@home is to use distributed computing to solve problems that would otherwise be intractable. Protein folding is a terrific problem to address with this approach:…
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Peptide and protein design
Peptides are short proteins. For proteins, one typically envisions a long chain of amino acids that has folded up on itself to form a compact blob that is capable of…
Read moreFunction of a cryptic pocket
One of the Bowman lab’s major foci is on finding and targeting cryptic pockets. Cryptic pockets are absent in experimentally derived structures of what a protein typically looks like but…
Read moreUnraveling the Mystery of Drug Specificity: The Case of Blebbistatin
When it comes to designing novel drugs, achieving specificity is a major challenge. An effective drug must bind tightly to its target protein while avoiding unwanted side effects that can…
Read moreUnderstanding Druggable States in a Protein Implicated in Parkinson’s Disease
and Viktor Belay Section 1: How does the breakdown of a brain cell’s recycling plant lead to neurodegenerative disease? Cellular functions are dependent on the activity of a vast ensemble…
Read moreForum Outage
Apologies to all for the unexpected downtime of the forum. An auto-update to the SSL certificate failed to go through and fixing it was delayed by the holidays. We hope…
Read moreUpdate for Those Using Advanced Remote Client Management Configurations
Hello Folders! We’ve been made aware of a potential issue for users who are using certain advanced manual configuration options for remote client management using fah-control. We actively recommend against…
Read moreUpdating our CPU and GPU counts
It’s always fun to watch the number of CPUs and GPUs running Folding@home! Earlier this year was particularly exciting as we saw explosive growth in Folding@home in response to our…
Read moreIntroducing COVID Moonshot weekly sprints: Help us discover a new therapy
Join our weekly sprints to prioritize compounds to make and test!
Read moreThanks for a great 2019
Thanks to everyone who has contributed to Folding@home over the past year! We greatly appreciate the computer time, human time, and financial resources you contribute to support our science. With…
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