Src kinase: Project 10471
In Project 10471 we at the Chodera lab are looking at Src kinase. The Src gene was first discovered as responsible for the tumorogenicity of Rous sarcoma virus. This gene…
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Fighting cancer on Folding@home: FDA approved kinase inhibitors
You may have noticed a trend in the type of proteins being simulated on Folding@home recently. A number of Folding@home labs are collaborating in an attempt to understand the role…
Read moreNew projects to help design selective inhibitors of protein methyltransferases
The Chodera lab has teamed up with Luo lab at MSKCC to study another important class of cancer targets: protein methyltransferases. These are protein-modifying enzymes that catalyze the transfer of…
Read moreInvestigating conformations accessible by Abl kinase- drug target for chronic myelogenous leukemia
Guest post by Sonya Hanson, postdoc in the Chodera lab. (Project 10472) We’re working our way through the kinase family here at the Chodera lab. You may have seen Danny’s…
Read moreDesigning good protein mimics by understanding their folding properties
Many drugs are small molecules that are able to block the active site of a protein, usually by binding to a small pocket. But for many proteins, especially signaling proteins…
Read moreFighting cancer on Folding@Home: EGFR
[Guest post by Daniel L. Parton of the Chodera Lab, Memorial Sloan-Kettering Cancer Center.] We’re about to roll out our first major F@h project on the new work server at…
Read moreIntroducing the Chodera lab at the Memorial Sloan-Kettering Cancer Center
The Chodera laboratory at the Memorial Sloan-Kettering Cancer Center (MSKCC) has just received our new Folding@Home server hardware, allowing us to tap into the 10+ PFLOP/s of computing resources generously provided…
Read moreRecent talk of results from Folding@home
Donors are often curious to hear about recent results. While one can read our papers, listed on our web site, those are fairly technical and intended for a biological or…
Read moreTwo new key results
We have two papers (one that just came out in PNAS and one that's about to come out in Physical Review Letters — papers #74 and #75 on our papers…
Read morePaper #72: Major new result from Folding@home: simulation of the millisecond timescale
Simulating protein folding on the millisecond timescale has been a major challenge for many years. When we started Folding@home, our first goal was to break the microsecond barrier. This barrier…
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