Happy 2026! (belated)
Thanks to everyone who helped get a lot of great science done in 2025! We’re looking forward to a great 2026 with you! First, the good stuff! Folding@home is continuing…
Read moreCategory: Science
Catching KRAS in the Act: Simulations Reveal New Paths for Targeted Protein Degradation
Mutations in the KRAS protein are among the most common drivers of human cancers, including lung, pancreatic, and colorectal tumors. Despite decades of effort, KRAS has been considered a particularly…
Read moreFAH is enabling AI developments
With all the advances happening in artificial intelligence (AI), itās natural to ask if one could develop an algorithm that predicts protein dynamics with far less computer time than running…
Read moreExperimental confirmation of spike dynamics
Early during the COVID-19 pandemic, our simulations of the coronavirus spike protein led us to predict that it opens up far more widely than previously thought. This opening reveals ācrypticā…
Read moreBRCA1 in breast cancer
About 2,300,000 people are diagnosed with breast cancer every year. Of these, approximately 70,000 have mutations in the breast cancer gene 1 (BRCA1), which encodes the BRCA1 protein. BRCA1 plays…
Read moreHappy new year 2025!
Thanks to everyone who participated in Folding@home this past year, and happy new year to you and yours! With your help, we’ve made a lot of progress towards understanding biology…
Read moreAn allosteric glue
There has been growing interest in developing drugs that bind two or more proteins to āglueā them together. Tacrolimus (aka FK506) is a famous example. Ā Tacrolimus is an immune-suppressant that…
Read morePredicting drugsā lipophilicity with Folding@home
Computational chemistry and machine learning continue to play an increasing role in drug discovery. One advance has been the increased accuracy with which we can predict the affinity of…
Read moreImproving protein design on Folding@home
The protein design field has been making great strides with the advent of new machine learning tools trained on large databases of protein structures and sequences. While designs coming from…
Read moreTackling Condensates
In recent years, scientists have identified a new type of compartment in cells, often called a condensate. These condensates form when weakly interacting proteins and RNA molecules segregate themselves from…
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