BRCA1 in breast cancer

About 2,300,000 people are diagnosed with breast cancer every year. Of these, approximately 70,000 have mutations in the breast cancer gene 1 (BRCA1), which encodes the BRCA1 protein. BRCA1 plays…

Read more

Happy new year 2025!

World map showing global distribution of Folding@home users from Nature Chemistry 13:651–659, 2021 paper.

Thanks to everyone who participated in Folding@home this past year, and happy new year to you and yours! With your help, we’ve made a lot of progress towards understanding biology…

Read more

An allosteric glue

There has been growing interest in developing drugs that bind two or more proteins to ā€œglueā€ them together. Tacrolimus (aka FK506) is a famous example. Ā Tacrolimus is an immune-suppressant that…

Read more

Tackling Condensates

In recent years, scientists have identified a new type of compartment in cells, often called a condensate. These condensates form when weakly interacting proteins and RNA molecules segregate themselves from…

Read more