BRCA1 in breast cancer
About 2,300,000 people are diagnosed with breast cancer every year. Of these, approximately 70,000 have mutations in the breast cancer gene 1 (BRCA1), which encodes the BRCA1 protein. BRCA1 plays…
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Understanding epigenetic cancer targets with Folding@home: Histone methyltransferases NSD1, NSD2, and NSD3
The Chodera Lab at the Memorial Sloan Kettering Cancer Center is now running a series of projects to study the conformational dynamics of histone methyltransferases to aid in the rational design of new small molecule…
Read moreFighting cancer on Folding@home: FDA approved kinase inhibitors
You may have noticed a trend in the type of proteins being simulated on Folding@home recently. A number of Folding@home labs are collaborating in an attempt to understand the role…
Read moreBreast Cancer and Her2 Kinase: Projects 9104-9114
We are continuing to make a big push into studying cancer. Next up, is work relevant for breast cancer. Specifically, we have started to study the Her2 Kinase, a part…
Read moreNew projects to help design selective inhibitors of protein methyltransferases
The Chodera lab has teamed up with Luo lab at MSKCC to study another important class of cancer targets: protein methyltransferases. These are protein-modifying enzymes that catalyze the transfer of…
Read moreFighting cancer on Folding@Home: EGFR
[Guest post by Daniel L. Parton of the Chodera Lab, Memorial Sloan-Kettering Cancer Center.] We’re about to roll out our first major F@h project on the new work server at…
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