A number of active projects on Folding@home right now aim to understand how different forms of the protein apolipoprotein E (ApoE) determine one’s risk of developing Alzheimer’s disease. Alzheimer’s disease…
Read moreFolding@home has long sought to understand how proteins self-assemble, or fold, into their functional structures and what the functional implications of dynamics within the context of a folded protein are.…
Read moreThe beta release of our new client software is going well. Thanks to everyone who has tried it out and given us feedback! If you haven’t already, you can download…
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When it comes to designing novel drugs, achieving specificity is a major challenge. An effective drug must bind tightly to its target protein while avoiding unwanted side effects that can…
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G proteins are essential molecular players in the intricate symphony of cellular signaling. From our vision to our sense of smell, neurotransmission to cell growth, G proteins are at the…
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This past year, we have largely focused on following through on our commitment to take on SARS-CoV-2. Looking ahead, there’s more work to be done on the pandemic, and we…
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For over 20 years, Folding@home has relied almost exclusively on government agencies like the National Science Foundation (NSF) and National Institutes of Health (NIH) for financial support. We’ve also been…
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TL;DR: During 2020, Folding@home was like the citizens’ fleet in the movie Star Wars: The Rise of Skywalker. Everyone came together to face a common foe, in this case the…
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As we all know, coronaviruses are a major threat to human health. In the past two decades these viruses have caused three epidemics: SARS in 2004, MERS in 2012, and…
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TL;DR: DeepMind’s AlphaFold marks a tremendous advance in our ability to predict the dominant structure of a protein. How proteins get there, and many other problems related to protein folding,…
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