The so-called “guardian of the genome”, p53 is a tumor suppression protein involved in regulating cell repair and apoptosis. Many cancer cells are able to proliferate because they have mutations…
Read moreThe stats system has now returned to normal operation. Sorry for the delay and any inconvenience this outage may have caused.
Read moreRead more.@PandeLab @vijaypande @foldingathome @Teamevga @EVGA_JacobF Team EVGA has broken 100 Billion!https://t.co/qDDu0B4jdW
— drougnor (@drougnor) August 31, 2016
A handful of Stanford-hosted FAH servers—including a stats server— will be undergoing scheduled maintenance starting today until Thursday. Assignments and points should not be affected; however, points may not be…
Read moreOur main web server for stats (https://foldingathome.org/) went down over the weekend due to a double failure. Â Our sysadmins are working on this today and expect it to be up…
Read more Published in Volume 126, Issue 9 (September 1, 2016) J Clin Invest. 2016;126(9):3526–3540. doi:10.1172/JCI86120. Jianing Xu, Can G. Pham, Steven K. Albanese, Yiyu Dong, Toshinao Oyama, Chung-Han Lee, Vanessa Rodrik-Outmezguine, Zhan Yao, Song Han,David Chen, Daniel L. Parton, John D. Chodera, Neal…
Read moreGenomic studies have linked mTORC1 pathway-activating mutations with exceptional response to treatment with allosteric inhibitors of mTORC1 called rapalogs. Rapalogs are approved for selected cancer types, including kidney and breast cancers. Here, we used sequencing data from 22 human kidney cancer cases to identify the activating mechanisms conferred by mTOR mutations observed in human cancers and advance precision therapeutics. mTOR mutations that clustered in focal adhesion kinase targetin…
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