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Month: October 2012

Version 7.2.9 of the Folding@home software is now available

October 30, 2012 by Vijay Pande

We are happy to announce that version 7.2.9 of the Folding@home software is now available at foldingathome.org. The ultimate goal of Folding@home has always been to support disease research but…

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The Folding@home article on Wikipedia is now a Featured Article

October 30, 2012 by Vijay Pande

Here's a guest post from Jesse Victors, one of the volunteers helping with Folding@home documentation. I am pleased to announce that the Folding@home article on Wikipedia is now a Featured…

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Life with Playstation ending, FAH team continuing to look to push the envelope

October 22, 2012 by Vijay Pande

For several years, we have worked closely with Sony to bring Folding@home to the PS3.  We're excited about what we've been able to do.  Since the PS3 started folding in…

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Unified GPU/SMP benchmarking scheme: equal points for equal work

October 21, 2012 by Vijay Pande

The current benchmarking calculations for SMP and GPU projects are performed on different machines since originally the SMP cores could not perform the calculations that the GPUs cores could and vice…

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Effects of familial mutations on the monomer structure of Aβ₄₂

October 21, 2012 by Tor Raswill

Lin YS, Pande VS. Biophysical Journal (Dec 2012) SUMMARY. This details some new results from Folding@home on Alzheimer’s Disease. ABSTRACT. Amyloid beta (Aβ) peptide plays an important role in Alzheimer’s…

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Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.

October 21, 2012 by Tor Raswill

Ring AM, Lin JX, Feng D, Mitra S, Rickert M, Bowman GR, Pande VS, Li P, Moraga I, Spolski R, Ozkan E, Leonard WJ, Garcia KC. Natural Immunology (Dec 2012)…

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Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7)

October 21, 2012 by Tor Raswill

Walker JR, Novick PA, Parsons WH, McGregor M, Zablocki J, Pande VS, Du Bois J. Proceedings of the National Academy of Sciences, USA (Dec 2012) SUMMARY. Here we use molecular…

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Simple few-state models reveal hidden complexity in protein folding.

October 21, 2012 by Tor Raswill

Beauchamp KA, McGibbon R, Lin YS, Pande VS. Proceedings of the National Academy of Sciences, USA (Oct 2012) SUMMARY. Markov State Models (MSMs) have been very helpful in analyzing protein…

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Slow unfolded-state structuring in Acyl-CoA binding protein folding revealed by simulation and experiment.

October 21, 2012 by Tor Raswill

Voelz VA, Jäger M, Yao S, Chen Y, Zhu L, Waldauer SA, Bowman GR, Friedrichs M, Bakajin O, Lapidus LJ, Weiss S, Pande VS. Journal of the American Chemical Society…

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Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

October 21, 2012 by Tor Raswill

A. M. Levin, D. L. Bates, A. M. Ring, J. T. Lin, L. Su, C. Krieg, G. R. Bowman, P. Novick, V. S. Pande, H. E. Kohrt, O. Boyman, C.…

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