The predicted structure of the headpiece of the Huntingtin protein and its implications on Huntington aggregation

Nicholas W. Kelley, Xuhui Huang, Stephen Tam, Christoph Spiess, Judith Frydman and Vijay S. Pande. Journal of Molecular Biology (2009)

SUMMARY. The aggregation of the Huntingtin (Htt) protein has been implicated as the cause of Huntington’s disease. However, how this aggregation occurs and why can happen so quickly is still largely unknown. Inspired by recent experimental results in the Frydman lab at Stanford, we have investigated a new possible mechanism for the aggregation of the Huntingtin (Htt) protein, with implications for better understanding how the Htt protein aggregates.