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Tag: beta-lactamase

Equilibrium fluctuations of a single folded protein reveal a multitude of potential cryptic allosteric sites

December 9, 2021 by Anton Thynell
Crystal structures of TEM-1 β-lactamase (A) in the absence of ligand and (B) in the presence of an allosteric inhibitor that reveals a cryptic binding site between helices 11 and 12.

A new paper from the Bowman lab proposes that potentially druggable cryptic allosteric sites may be even more ubiquitous than previously thought, and that our new simulation methods should be a valuable means of guiding the search for such sites.

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