The Chodera Lab at the Memorial Sloan Kettering Cancer Center is now running a series of projects to study the conformational dynamics of histone methyltransferases to aid in the rational design of new small molecule…
Read moremTOR, a serine/threonine kinase first discovered in 1994, is a key signaling node that integrates a number of inputs to control processes such as cell growth and metabolism, among others.…
Read moreThe immune checkpoint receptor PD-1 and its ligand, PD-L1, have emerged as key regulators of anti-tumor immunity in humans. Recently, we reported an ultra-high-affinity PD-1 mutant, termed high-affinity consensus (HAC) PD-1, which shows superior therapeutic efficacy in mice compared with antibodies. However, the molecular details underlying the action of this agent remain incompletely understood, and a molecular view of PD-1/PD-L1 interactions in general is only beginning to emerge. Here, we r…
Read moreTEM β-lactamase confers bacteria with resistance to many antibiotics and rapidly evolves activity against new drugs. However, functional changes are not easily explained by differences in crystal structures. We employ Markov state models to identify hidden conformations and explore their role in determining TEM’s specificity. We integrate these models with existing drug-design tools to create a new technique, called Boltzmann docking, which better predicts TEM specificity by accounting for con…
Read moreThe so-called “guardian of the genome”, p53 is a tumor suppression protein involved in regulating cell repair and apoptosis. Many cancer cells are able to proliferate because they have mutations…
Read moreThe stats system has now returned to normal operation. Sorry for the delay and any inconvenience this outage may have caused.
Read moreRead more.@PandeLab @vijaypande @foldingathome @Teamevga @EVGA_JacobF Team EVGA has broken 100 Billion!https://t.co/qDDu0B4jdW
— drougnor (@drougnor) August 31, 2016
A handful of Stanford-hosted FAH servers—including a stats server— will be undergoing scheduled maintenance starting today until Thursday. Assignments and points should not be affected; however, points may not be…
Read moreOur main web server for stats (https://foldingathome.org/) went down over the weekend due to a double failure. Â Our sysadmins are working on this today and expect it to be up…
Read more Published in Volume 126, Issue 9 (September 1, 2016) J Clin Invest. 2016;126(9):3526–3540. doi:10.1172/JCI86120. Jianing Xu, Can G. Pham, Steven K. Albanese, Yiyu Dong, Toshinao Oyama, Chung-Han Lee, Vanessa Rodrik-Outmezguine, Zhan Yao, Song Han,David Chen, Daniel L. Parton, John D. Chodera, Neal…
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