Thanks for a great 2019
Thanks to everyone who has contributed to Folding@home over the past year! We greatly appreciate the computer time, human time, and financial resources you contribute to support our science. With…
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Octanol-water partition coefficient measurements for the SAMPL6 blind prediction challenge.
Partition coefficients describe the equilibrium partitioning of a single, defined charge state of a solute between two liquid phases in contact, typically a neutral solute. Octanol-water partition coefficients ([Formula: see text]), or their logarithms (log P), are frequently used as a measure of lipophilicity in drug discovery. The partition coefficient is a physicochemical property that captures the thermodynamics of relative solvation between aqueous and nonpolar phases, and the…
Read moreTax deductible gifts to FAH
As the end of the year approaches, please consider supporting Folding@home by making a tax deductible gift through Washington University at this link (please make sure Folding@home is specified under…
Read moreUpload issues
We’re working on resolving issues with uploads to servers at Temple University (155.247.166.*). There appears to be a combination of 1) networking issues and 2) pausing of work units resulting…
Read moreA Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization.
Id helix-loop-helix (HLH) proteins (Id1-4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states. Id proteins are primarily expressed during development to inhibit differentiation, but they become re-expressed in adult tissues in diseases of the vasculature and cancer. We show that the genetic loss of Id1/Id3 reduces ocular neovascularization in mouse models of wet age-related macular degeneration (AMD) a…
Read moreBonus recredit
This past June, a server error led to a failure to assign bonus points to a number of work units. We corrected the error as soon as it was detected.…
Read moreAncestral reconstruction reveals mechanisms of ERK regulatory evolution.
Ancestral reconstruction reveals mechanisms of ERK regulatory evolution. Elife. 2019 Aug 13;8: Authors: Sang D, Pinglay S, Wiewiora RP, Selvan ME, Lou HJ, Chodera JD, Turk BE, Gümüş ZH, Holt…
Read moreSmall-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
Related Articles Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nat Commun. 2019 Jun 19;10(1):2691 Authors: Minuesa G, Albanese SK, Xie W, Kazansky Y, Worroll D, Chow A,…
Read moreThe dynamic conformational landscape of the protein methyltransferase SETD8.
The dynamic conformational landscape of the protein methyltransferase SETD8. Elife. 2019 May 13;8: Authors: Chen S, Wiewiora RP, Meng F, Babault N, Ma A, Yu W, Qian K, Hu H,…
Read moreA Site-Specific ImmunoPET Tracer to Image PD-L1.
A Site-Specific ImmunoPET Tracer to Image PD-L1. Mol Pharm. 2019 Mar 15;: Authors: Wissler HL, Ehlerding EB, Lyu Z, Zhao Y, Zhang S, Eshraghi A, Buuh ZY, McGuth JC, Guan…
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