Bonus recredit
This past June, a server error led to a failure to assign bonus points to a number of work units. We corrected the error as soon as it was detected.…
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Ancestral reconstruction reveals mechanisms of ERK regulatory evolution.
Ancestral reconstruction reveals mechanisms of ERK regulatory evolution. Elife. 2019 Aug 13;8: Authors: Sang D, Pinglay S, Wiewiora RP, Selvan ME, Lou HJ, Chodera JD, Turk BE, Gümüş ZH, Holt…
Read moreSmall-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
Related Articles Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nat Commun. 2019 Jun 19;10(1):2691 Authors: Minuesa G, Albanese SK, Xie W, Kazansky Y, Worroll D, Chow A,…
Read moreThe dynamic conformational landscape of the protein methyltransferase SETD8.
The dynamic conformational landscape of the protein methyltransferase SETD8. Elife. 2019 May 13;8: Authors: Chen S, Wiewiora RP, Meng F, Babault N, Ma A, Yu W, Qian K, Hu H,…
Read moreA Site-Specific ImmunoPET Tracer to Image PD-L1.
A Site-Specific ImmunoPET Tracer to Image PD-L1. Mol Pharm. 2019 Mar 15;: Authors: Wissler HL, Ehlerding EB, Lyu Z, Zhao Y, Zhang S, Eshraghi A, Buuh ZY, McGuth JC, Guan…
Read moreAn in-depth article with Greg Bowman, the new director of Folding@Home.
Read more in this article from Washington University in St Louis.
Read moreCooperative Changes in Solvent Exposure Identify Cryptic Pockets, Switches, and Allosteric Coupling.
Proteins are dynamic molecules that undergo conformational changes to a broad spectrum of different excited states. Unfortunately, the small populations of these states make it difficult to determine their structures or functional implications. Computer simulations are an increasingly powerful means to identify and characterize functionally relevant excited states. However, this advance has uncovered a further challenge: it can be extremely difficult to identify the most salient feature…
Read moreFluorinated Aromatic Monomers as Building Blocks to Control α-Peptoid Conformation and Structure.
Peptoids are peptidomimetics of interest in the fields of drug development and biomaterials. However, obtaining stable secondary structures is challenging and designing these requires effective control of the peptoid tertiary amide cis/trans equilibrium. Herein, we report new fluorine containing aromatic monomers that can control peptoid conformation. Specifically, we demonstrate that a fluoro-pyridine group can be used to circumvent the need for monomer chirality to control the cis/tra…
Read moreFolding@home’s New Director: Prof. Gregory Bowman
After a successful transition period working alongside Dr. Pande as a co-Director, I’m pleased to begin serving as the Director of Folding@home. I’d like to take this opportunity to thank…
Read moreNative client points adjustment
It has come to our attention that the points for native client work units are over-inflated relative to their scientific value, so we will be reducing the credit for these…
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