News

Octanol-water partition coefficient measurements for the SAMPL6 blind prediction challenge.

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Partition coefficients describe the equilibrium partitioning of a single, defined charge state of a solute between two liquid phases in contact, typically a neutral solute. Octanol-water partition coefficients ([Formula: see text]), or their logarithms (log P), are frequently used as a measure of lipophilicity in drug discovery. The partition coefficient is a physicochemical property that captures the thermodynamics of relative solvation between aqueous and nonpolar phases, and the…

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Tax deductible gifts to FAH

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As the end of the year approaches, please consider supporting Folding@home by making a tax deductible gift through Washington University at this link (please make sure Folding@home is specified under…

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Upload issues

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We’re working on resolving issues with uploads to servers at Temple University (155.247.166.*). There appears to be a combination of 1) networking issues and 2) pausing of work units resulting…

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A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization.

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Id helix-loop-helix (HLH) proteins (Id1-4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states. Id proteins are primarily expressed during development to inhibit differentiation, but they become re-expressed in adult tissues in diseases of the vasculature and cancer. We show that the genetic loss of Id1/Id3 reduces ocular neovascularization in mouse models of wet age-related macular degeneration (AMD) a…

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Bonus recredit

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This past June, a server error led to a failure to assign bonus points to a number of work units. We corrected the error as soon as it was detected.…

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