Tax deductible gifts to FAH
As the end of the year approaches, please consider supporting Folding@home by making a tax deductible gift through Washington University at this link (please make sure Folding@home is specified under…
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Upload issues
We’re working on resolving issues with uploads to servers at Temple University (155.247.166.*). There appears to be a combination of 1) networking issues and 2) pausing of work units resulting…
Read moreA Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization.
Id helix-loop-helix (HLH) proteins (Id1-4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states. Id proteins are primarily expressed during development to inhibit differentiation, but they become re-expressed in adult tissues in diseases of the vasculature and cancer. We show that the genetic loss of Id1/Id3 reduces ocular neovascularization in mouse models of wet age-related macular degeneration (AMD) a…
Read moreBonus recredit
This past June, a server error led to a failure to assign bonus points to a number of work units. We corrected the error as soon as it was detected.…
Read moreAncestral reconstruction reveals mechanisms of ERK regulatory evolution.
Ancestral reconstruction reveals mechanisms of ERK regulatory evolution. Elife. 2019 Aug 13;8: Authors: Sang D, Pinglay S, Wiewiora RP, Selvan ME, Lou HJ, Chodera JD, Turk BE, Gümüş ZH, Holt…
Read moreSmall-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
Related Articles Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nat Commun. 2019 Jun 19;10(1):2691 Authors: Minuesa G, Albanese SK, Xie W, Kazansky Y, Worroll D, Chow A,…
Read moreThe dynamic conformational landscape of the protein methyltransferase SETD8.
The dynamic conformational landscape of the protein methyltransferase SETD8. Elife. 2019 May 13;8: Authors: Chen S, Wiewiora RP, Meng F, Babault N, Ma A, Yu W, Qian K, Hu H,…
Read moreA Site-Specific ImmunoPET Tracer to Image PD-L1.
A Site-Specific ImmunoPET Tracer to Image PD-L1. Mol Pharm. 2019 Mar 15;: Authors: Wissler HL, Ehlerding EB, Lyu Z, Zhao Y, Zhang S, Eshraghi A, Buuh ZY, McGuth JC, Guan…
Read moreAn in-depth article with Greg Bowman, the new director of Folding@Home.
Read more in this article from Washington University in St Louis.
Read moreCooperative Changes in Solvent Exposure Identify Cryptic Pockets, Switches, and Allosteric Coupling.
Proteins are dynamic molecules that undergo conformational changes to a broad spectrum of different excited states. Unfortunately, the small populations of these states make it difficult to determine their structures or functional implications. Computer simulations are an increasingly powerful means to identify and characterize functionally relevant excited states. However, this advance has uncovered a further challenge: it can be extremely difficult to identify the most salient feature…
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