COVID Moonshot Sprint 10
Sprint 10 aims to help optimize the P1 pocket substituent to work around metabolism issues with our current best lead compounds. We’ve been quiet lately, but that’s because we’ve been…
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Understanding the impact of the lipid bilayer on ion channel function
Contributed by Sergio Perez Conesa All our thoughts, movements, and heartbeats are governed by electrical signals in our bodies. These electrical signals are nothing but charged particles, called ions, crossing…
Read moreMaximizing the impact of Folding@home by engaging industry collaborators
For over 20 years, Folding@home has relied almost exclusively on government agencies like the National Science Foundation (NSF) and National Institutes of Health (NIH) for financial support. We’ve also been…
Read moreOverview of the SAMPL6 pKa challenge: evaluating small molecule microscopic and macroscopic pKa predictions
The prediction of acid dissociation constants (pK(a)) is a prerequisite for predicting many other properties of a small molecule, such as its protein-ligand binding affinity, distribution coefficient (log D), membrane permeability, and solubility. The prediction of each of these properties requires knowledge of the relevant protonation states and solution free energy penalties of each state. The SAMPL6 pK(a) Challenge was the first time that a separate challenge was conducted for evaluating…
Read more 2020 in review, and happy new year 2021!
TL;DR: During 2020, Folding@home was like the citizens’ fleet in the movie Star Wars: The Rise of Skywalker. Everyone came together to face a common foe, in this case the…
Read moreSARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential
As we all know, coronaviruses are a major threat to human health. In the past two decades these viruses have caused three epidemics: SARS in 2004, MERS in 2012, and…
Read moreProtein folding and related problems remain unsolved despite AlphaFold’s advance
TL;DR: DeepMind’s AlphaFold marks a tremendous advance in our ability to predict the dominant structure of a protein. How proteins get there, and many other problems related to protein folding,…
Read moreForum Outage
Apologies to all for the unexpected downtime of the forum. An auto-update to the SSL certificate failed to go through and fixing it was delayed by the holidays. We hope…
Read moreUpdate for Those Using Advanced Remote Client Management Configurations
Hello Folders! We’ve been made aware of a potential issue for users who are using certain advanced manual configuration options for remote client management using fah-control. We actively recommend against…
Read more20th-anniversary live stream
To celebrate the 20th anniverary of Foldingathome we are hosting a celebration live stream: When? Wednesday the 18th at Noon – 3:30 PM pacific time Where? Twitch.tv/foldingathomehomedotorg Recorded video: https://www.twitch.tv/videos/807988760…
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