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Category: Meet the classic paper

Meet the classic paper: Sorin and Pande 2005

March 17, 2022 by Vincent Voelz
Figure 12 from the Sorin and Pande 2005 paper on helix-coil kinetics, showing complex kinetics between a surprising variety of non-helical states as well.

We revisit a classic paper from Folding@home’s early days in which the supposedly simple dynamics of a simple peptide turns out to be much more exciting than expected.

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Classic paper: Improved coarse-graining of Markov state models via explicit consideration of statistical uncertainty

December 9, 2021 by Anton Thynell
Hierarchy of microstate clusters into macrostates achieved with Bayesian Agglomerative Clustering (BACE)

This classic paper from Folding@home Director Greg Bowman describes a Bayesian approach to clustering microstates into metastable states for building Markov state models, a foundational Folding@home technology.

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