Reunion in Madison
Last week we had a really nice meeting in Madison, WI on combining simulations and machine learning to understand protein dynamics. This meeting was hosted through CECAM (Centre EuropĂ©en de…
Read moreAuthor: Greg Bowman
Experimental confirmation of spike dynamics
Early during the COVID-19 pandemic, our simulations of the coronavirus spike protein led us to predict that it opens up far more widely than previously thought. This opening reveals âcrypticâ…
Read moreBRCA1 in breast cancer
About 2,300,000 people are diagnosed with breast cancer every year. Of these, approximately 70,000 have mutations in the breast cancer gene 1 (BRCA1), which encodes the BRCA1 protein. BRCA1 plays…
Read moreStand up for Science
Please join us as we Stand Up for Science in cities across the US on Friday March 7. You can find more details on the main event in Washington DC…
Read moreNew client v8.4.9
If you haven’t already, we invite you to check out the latest release of the Folding@home client (v8.4.9)! This version makes it much easier to create and join teams. You…
Read moreHappy new year 2025!
Thanks to everyone who participated in Folding@home this past year, and happy new year to you and yours! With your help, we’ve made a lot of progress towards understanding biology…
Read moreAn allosteric glue
There has been growing interest in developing drugs that bind two or more proteins to âglueâ them together. Tacrolimus (aka FK506) is a famous example. Â Tacrolimus is an immune-suppressant that…
Read morePeptide and protein design
Peptides are short proteins. For proteins, one typically envisions a long chain of amino acids that has folded up on itself to form a compact blob that is capable of…
Read moreFunction of a cryptic pocket
One of the Bowman labâs major foci is on finding and targeting cryptic pockets. Cryptic pockets are absent in experimentally derived structures of what a protein typically looks like but…
Read moreThe Bowman Lab Rig
Folding@home is an unmatched resource for running molecular dynamics simulations on a massive scale. The need for significant computational resources doesn’t end with data generation though, as analyzing all the…
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