One major benefit of the new Folding@home streaming infrastructure (FSI) over the previous FAH “classic” infrastructure (FCI) is that FSI is streaming. So we get clients running on a trajectory 24×7, whereas FCI has timeouts which can take a while to meet, thus making long trajectories harder to calculate.
Longer trajectories are important to us because Markov State Models (MSMs) need some minimal trajectory length to be useful. The streaming approach gets us there faster and more efficiently (in wall clock time) with fewer wasted Work Units.