About four months ago, we started a new set of projects to understand the dynamics of some of the key proteins involved in vision. Now, we have about 600 microseconds of simulation and have begun some preliminary analysis of the data. Excitingly, it appears we may already have captured the conformational change we were targeting. More data will be needed to improve the statistical significance of our results, but we are increasingly confident that we’ll be able to begin understanding some of the conformational changes required for vision and, eventually , how mutations lead to various blinding diseases.
