Our recent work on understanding how protein misfolding occurs (http://www.cell.com/biophysj/abstract/S0006-3495(14)00722-X) has shed light on the nature of misfolding and potential subsequent aggregation (relevant for protein misfolding disease), demonstrating that misfolded states are more prevalent than would be expected, especially due to their metastability (once you get into a misfolded state, it’s really hard to get out of it).
The work was also recently highlighted in a separate article in the Journal (http://www.cell.com/biophysj/abstract/S0006-3495(14)00723-1 ).