I started a few projects to study the dynamics of a protein called dihydrofolate reductase (or just DHFR for short) a few months ago and now have enough data to begin analysis. DHFR is an exciting protein to study because it is an important target for both anticancer and antibacterial drugs. There is also substantial experimental evidence that DHFR’s conformational dynamics are important for its function but our understanding of these dynamics is still incomplete. More detailed insights from these projects could provide insight into how to manipulate DHFR’s dynamics for therapeutic purposes.
