Emergence of Glass-like Behavior in Markov State Models of Protein Folding Dynamics.

J. K. Weber, R. Jack, and V. S. Pande.  JACS, in press (2013)

With all of our work in protein folding, we can step back and ask questions of what’s common, especially for protein misfolding.  This paper is a start in this direction, using a new method to probe our models.  This is just the tip of the iceberg as in later papers (under review), we will show how this approach can give insight into protein misfolding, giving new hypotheses for how protein misfolding (relevant in many diseases, such as Alzheimer’s and Parkinson’s) could arise.