Stanford scientists and collaborators boost potency, reduce side effects of IL-2 protein used to treat cancer

Today, I'm highlighting the work primarily out of Chris Garcia's lab at Stanford Medical School.  The Garcia lab had a very exciting idea on how to re-engineer a very important protein and the Pande lab played a part by providing computer simulations to help understand the mechanism by which the new protein worked.  The results are very exciting.  Check out the link below for more details.

SUMMARY.  The utility of a naturally occurring protein given, sometimes to great effect, as a drug to treat advanced cancers is limited by the severe side effects it sometimes causes. But a Stanford University School of Medicine scientist has generated a mutant version of the protein whose modified shape renders it substantially more potent than the natural protein while reducing its toxicity.