How accurate are Folding@home’s predictions?

The vast amount of information we obtain from Folding@home on the nature of folding and misfolding (e.g. pathways, rates, free energy, etc) continues to demonstrate a quantitative validation to laboratory results. We are constantly testing Folding@home’s results for their accuracy, as this is a critical aspect of our work –– to make predictions relevant for experiment.

We have a tight coupling between simulations and experiments. New simulations lead to new experiments which lead to new simulations. With this iterative process, we hope to first gain a better understanding of folding and misfolding, and then apply this understanding to the development of novel drugs and other types of therapeutics.